View source for 7yzd


==Crystal structure of the zebrafish FoxH1 bound to the TGTTTACT site (fkh motif GTAAACA)==
<StructureSection load='7yzd' size='340' side='right'caption='[[7yzd]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7yzd]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YZD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yzd OCA], [https://pdbe.org/7yzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yzd RCSB], [https://www.ebi.ac.uk/pdbsum/7yzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yzd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FOXH1_DANRE FOXH1_DANRE] Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry.<ref>PMID:10996071</ref> <ref>PMID:10996072</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Danio rerio]]
[[Category: Large Structures]]
[[Category: Macias MJ]]
[[Category: Pluta R]]