View source for 7yzg


==Crystal structure of the Xenopus FoxH1 bound to the TGTGGATT site==
<StructureSection load='7yzg' size='340' side='right'caption='[[7yzg]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7yzg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YZG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.82&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yzg OCA], [https://pdbe.org/7yzg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yzg RCSB], [https://www.ebi.ac.uk/pdbsum/7yzg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yzg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FOXH1_XENLA FOXH1_XENLA] Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Upon TGF-beta induction, forms a transcriptionally active complex with smad2 and smad4 called activin-responsive factor 1 (ARF1), which binds a site on the mix-B/mix.2 promoter called the activin response element (ARE). Binds to activated smads and the ARE with much lower affinity than fast3. Necessary for the first steps in mesoderm specification, directly inducing mesodermal genes. Acts with fast3 to control the convergent extension movements of gastrulation. Binds to the proximal element (PE) of the gsc gene and cooperates with gtf2ird1/wbscr11 and SMAD proteins to regulate gsc transcription.<ref>PMID:10349617</ref> <ref>PMID:10473623</ref> <ref>PMID:10572039</ref> <ref>PMID:11937490</ref> <ref>PMID:12050132</ref> <ref>PMID:8878477</ref> <ref>PMID:9288972</ref> 

==See Also==
*[[FOX 3D structures|FOX 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Xenopus laevis]]
[[Category: Macias MJ]]
[[Category: Pluta R]]