View source for 7zdz


==Cryo-EM structure of the human inward-rectifier potassium 2.1 channel (Kir2.1)==
<StructureSection load='7zdz' size='340' side='right'caption='[[7zdz]], [[Resolution|resolution]] 4.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7zdz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZDZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZDZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zdz OCA], [https://pdbe.org/7zdz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zdz RCSB], [https://www.ebi.ac.uk/pdbsum/7zdz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zdz ProSAT]</span></td></tr>
</table>
== Disease ==
[[https://www.uniprot.org/uniprot/KCNJ2_HUMAN KCNJ2_HUMAN]] Familial short QT syndrome;Familial atrial fibrillation;Andersen-Tawil syndrome. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[[https://www.uniprot.org/uniprot/KCNJ2_HUMAN KCNJ2_HUMAN]] Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fagnen C]]
[[Category: Fernandes CAH]]
[[Category: Venien-Bryan C]]
[[Category: Zuniga D]]