View source for 7zgk


==Trypanosoma brucei gambiense ISG65 in complex with human complement component C3b==
<StructureSection load='7zgk' size='340' side='right'caption='[[7zgk]], [[Resolution|resolution]] 3.59&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7zgk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Trypanosoma_brucei_gambiense Trypanosoma brucei gambiense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZGK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.59&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zgk OCA], [https://pdbe.org/7zgk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zgk RCSB], [https://www.ebi.ac.uk/pdbsum/7zgk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zgk ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
African Trypanosomes have developed elaborate mechanisms to escape the adaptive immune response, but little is known about complement evasion particularly at the early stage of infection. Here we show that ISG65 of the human-infective parasite Trypanosoma brucei gambiense is a receptor for human complement factor C3 and its activation fragments and that it takes over a role in selective inhibition of the alternative pathway C5 convertase and thus abrogation of the terminal pathway. No deposition of C4b, as part of the classical and lectin pathway convertases, was detected on trypanosomes. We present the cryo-electron microscopy (EM) structures of native C3 and C3b in complex with ISG65 which reveal a set of modes of complement interaction. Based on these findings, we propose a model for receptor-ligand interactions as they occur at the plasma membrane of blood-stage trypanosomes and may facilitate innate immune escape of the parasite.

Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction.,Sulzen H, Began J, Dhillon A, Kereiche S, Pompach P, Votrubova J, Zahedifard F, Subrtova A, Safner M, Hubalek M, Thompson M, Zoltner M, Zoll S Nat Commun. 2023 Apr 27;14(1):2403. doi: 10.1038/s41467-023-37988-7. PMID:37105991<ref>PMID:37105991</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Trypanosoma brucei gambiense]]
[[Category: Suelzen H]]
[[Category: Zoll S]]