View source for 7zhn


==Crystal structure of TTBK1 in complex with AMG28==
<StructureSection load='7zhn' size='340' side='right'caption='[[7zhn]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7zhn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZHN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=VP7:4-(2-amino-5,6,7,8-tetrahydropyrimido[4,5 3,4]cyclohepta[1,2-b]indol-11-yl)-2-methylbut-3-yn-2-ol'>VP7</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zhn OCA], [https://pdbe.org/7zhn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zhn RCSB], [https://www.ebi.ac.uk/pdbsum/7zhn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zhn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TTBK1_HUMAN TTBK1_HUMAN] Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.<ref>PMID:16923168</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Axtman A]]
[[Category: Chaikuad A]]
[[Category: Knapp S]]