View source for 7zl3


==Signal peptide mimicry primes Sec61 for client-selective inhibition==
<StructureSection load='7zl3' size='340' side='right'caption='[[7zl3]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7zl3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZL3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3EG:(2S)-2-AMINO-4,4,4-TRIFLUOROBUTANOIC+ACID'>3EG</scene>, <scene name='pdbligand=JMO:(2R)-4-cyano-2-[(2~{S})-2-(methylamino)propanoyl]oxy-butanoic+acid'>JMO</scene>, <scene name='pdbligand=JMX:(2S)-3-[1-[(4-bromophenyl)methyl]indol-3-yl]-2-(methylamino)propanoic+acid'>JMX</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zl3 OCA], [https://pdbe.org/7zl3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zl3 RCSB], [https://www.ebi.ac.uk/pdbsum/7zl3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zl3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A6P3YN15_SHEEP A0A6P3YN15_SHEEP] 
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Ovis aries]]
[[Category: Synthetic construct]]
[[Category: Paavilainen O V]]
[[Category: Rehan S]]