View source for 7ztw


==Crystal Structure of Human Parechovirus 1 2A protein==
<StructureSection load='7ztw' size='340' side='right'caption='[[7ztw]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ztw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_parechovirus_1 Human parechovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZTW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZTW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ztw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ztw OCA], [https://pdbe.org/7ztw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ztw RCSB], [https://www.ebi.ac.uk/pdbsum/7ztw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ztw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/POLG_HPE1H POLG_HPE1H] Capsid proteins VP0, VP2, VP3 form a closed capsid enclosing the viral positive strand RNA genome. Capsid proteins interact with host alpha-V/beta-3 integrin heterodimer to provide virion attachment target cell. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis.<ref>PMID:11160695</ref>   Protein 2A: Is not a protease.  Protein 2B: Affects membrane integrity and cause an increase in membrane permeability.  Protein 2C: Associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).  Protein 3A, via its hydrophobic domain, serves as membrane anchor.  Protease 3C: cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind cooperatively to the protease (By similarity).  RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals.[PROSITE-ProRule:PRU00539]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human parechovirus 1]]
[[Category: Large Structures]]
[[Category: Perrakis A]]
[[Category: Von Castelmur E]]