View source for 7zvn


==Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 1.87 A resolution==
<StructureSection load='7zvn' size='340' side='right'caption='[[7zvn]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7zvn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZVN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AS:2-DEOXY-ADENOSINE+-5-THIO-MONOPHOSPHATE'>AS</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GS:GUANOSINE-5-THIO-MONOPHOSPHATE'>GS</scene>, <scene name='pdbligand=K2F:2-methoxyethyl-adenosine-5-thiophosphate'>K2F</scene>, <scene name='pdbligand=K39:2-methoxyethyl-guanosine-5-thiophosphate'>K39</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=N7X:5-O-[(R)-hydroxy(sulfanylidene)-lambda~5~-phosphanyl]-2-O-(2-methoxyethyl)-5-methylcytidine'>N7X</scene>, <scene name='pdbligand=OKN:5-methyl-2-deoxycytidine-5-phosphorothioate'>OKN</scene>, <scene name='pdbligand=PST:THYMIDINE-5-THIOPHOSPHATE'>PST</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zvn OCA], [https://pdbe.org/7zvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zvn RCSB], [https://www.ebi.ac.uk/pdbsum/7zvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zvn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ANXA2_HUMAN ANXA2_HUMAN] Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Anderson B]]
[[Category: Hyjek-Skladanowska M]]
[[Category: Mykhaylyk V]]
[[Category: Nowotny M]]
[[Category: Orr C]]
[[Category: Seth P]]
[[Category: Skowronek K]]
[[Category: Wagner A]]