View source for 7zwm


==Pfs48/45 central and C-terminal domains bound to Fab fragments of monoclonal antibody 10D8 and 32F3==
<StructureSection load='7zwm' size='340' side='right'caption='[[7zwm]], [[Resolution|resolution]] 3.69&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7zwm]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZWM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.69&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zwm OCA], [https://pdbe.org/7zwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zwm RCSB], [https://www.ebi.ac.uk/pdbsum/7zwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zwm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/P4548_PLAF7 P4548_PLAF7] Gametocyte surface protein required for male fertility.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
An effective malaria vaccine remains a global health priority and vaccine immunogens which prevent transmission of the parasite will have important roles in multi-component vaccines. One of the most promising candidates for inclusion in a transmission-blocking malaria vaccine is the gamete surface protein Pfs48/45, which is essential for development of the parasite in the mosquito midgut. Indeed, antibodies which bind Pfs48/45 can prevent transmission if ingested with the parasite as part of the mosquito bloodmeal. Here we present the structure of full-length Pfs48/45, showing its three domains to form a dynamic, planar, triangular arrangement. We reveal where transmission-blocking and non-blocking antibodies bind on Pfs48/45. Finally, we demonstrate that antibodies which bind across this molecule can be transmission-blocking. These studies will guide the development of future Pfs48/45-based vaccine immunogens.

Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.,Ko KT, Lennartz F, Mekhaiel D, Guloglu B, Marini A, Deuker DJ, Long CA, Jore MM, Miura K, Biswas S, Higgins MK Nat Commun. 2022 Sep 24;13(1):5603. doi: 10.1038/s41467-022-33379-6. PMID:36153317<ref>PMID:36153317</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7zwm" style="background-color:#fffaf0;"></div>

==See Also==
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Plasmodium falciparum]]
[[Category: Higgins MK]]
[[Category: Ko KT]]
[[Category: Lennartz FL]]