View source for 7zyi


==Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody==
<StructureSection load='7zyi' size='340' side='right'caption='[[7zyi]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7zyi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZYI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.88&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CHO:GLYCOCHENODEOXYCHOLIC+ACID'>CHO</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zyi OCA], [https://pdbe.org/7zyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zyi RCSB], [https://www.ebi.ac.uk/pdbsum/7zyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zyi ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN] Familial hypercholanemia. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN] As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins (PubMed:14660639, PubMed:24867799, PubMed:34060352, PubMed:8132774). It is strictly dependent on the extracellular presence of sodium (PubMed:14660639, PubMed:24867799, PubMed:34060352, PubMed:8132774). It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate (PubMed:14660639, PubMed:34060352). Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (PubMed:33222321).<ref>PMID:14660639</ref> <ref>PMID:24867799</ref> <ref>PMID:34060352</ref> <ref>PMID:8132774</ref> <ref>PMID:33222321</ref>   (Microbial infection) Acts as a receptor for hepatitis B virus.<ref>PMID:23150796</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Agrawal P]]
[[Category: Bang-Sorensen R]]
[[Category: Irobalieva RN]]
[[Category: Kossiakoff AA]]
[[Category: Liu H]]
[[Category: Locher KP]]
[[Category: Mukherjee S]]
[[Category: Nosol K]]
[[Category: Stieger B]]