View source for 8adb


==Viral tegument-like DUBs==
<StructureSection load='8adb' size='340' side='right'caption='[[8adb]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8adb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Waddlia_chondrophila Waddlia chondrophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ADB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ADB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8adb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8adb OCA], [https://pdbe.org/8adb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8adb RCSB], [https://www.ebi.ac.uk/pdbsum/8adb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8adb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/D6YWY5_WADCW D6YWY5_WADCW] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Distinct families of eukaryotic deubiquitinases (DUBs) are regulators of ubiquitin signaling. Here, we report on the presence of an additional DUB class broadly distributed in eukaryotes and several bacteria. The only described members of this family are the large tegument proteins of herpesviruses, which are attached to the outside of the viral capsid. By using a bioinformatics screen, we have identified distant homologs of this VTD (Viral tegument-like DUB) family in vertebrate transposons, fungi, insects, nematodes, cnidaria, protists and bacteria. While some VTD activities resemble viral tegument DUBs in that they favor K48-linked ubiquitin chains, other members are highly specific for K6- or K63-linked ubiquitin chains. The crystal structures of K48- and K6-specific members reveal considerable differences in ubiquitin recognition. The VTD family likely evolved from non-DUB proteases and spread through transposons, many of which became 'domesticated', giving rise to the Drosophila male sterile (3)76Ca gene and several nematode genes with male-specific expression.

A widely distributed family of eukaryotic and bacterial deubiquitinases related to herpesviral large tegument proteins.,Erven I, Abraham E, Hermanns T, Baumann U, Hofmann K Nat Commun. 2022 Dec 10;13(1):7643. doi: 10.1038/s41467-022-35244-y. PMID:36496440<ref>PMID:36496440</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 8adb" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Waddlia chondrophila]]
[[Category: Abraham ET]]
[[Category: Baumann U]]
[[Category: Erven I]]
[[Category: Hermanns T]]
[[Category: Hofmann K]]