View source for 8afw


==Tube assembly of Atg18-WT==
<StructureSection load='8afw' size='340' side='right'caption='[[8afw]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8afw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AFW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8afw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8afw OCA], [https://pdbe.org/8afw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8afw RCSB], [https://www.ebi.ac.uk/pdbsum/8afw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8afw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ATG18_YEAST ATG18_YEAST] The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). May negatively regulate FAB1 activity by sequestering or masking VAC7 from FAB1. Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication. With ATG2, protects ATG8 from ATG4-mediated cleavage.<ref>PMID:11470404</ref> <ref>PMID:11536337</ref> <ref>PMID:11707261</ref> <ref>PMID:11739783</ref> <ref>PMID:14723849</ref> <ref>PMID:15155809</ref> <ref>PMID:15194695</ref> <ref>PMID:16876790</ref> <ref>PMID:17699591</ref> <ref>PMID:18586673</ref> <ref>PMID:18769150</ref> <ref>PMID:19037259</ref> <ref>PMID:20154084</ref> <ref>PMID:22108003</ref> <ref>PMID:22728243</ref> <ref>PMID:22787281</ref> <ref>PMID:24905091</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Fromm S]]
[[Category: Gopaldass N]]
[[Category: Mann D]]
[[Category: Martinez-Sanchez A]]
[[Category: Mayer A]]
[[Category: Sachse C]]