View source for 8agg


==Structure of the Legionella phosphocholine hydrolase Lem3==
<StructureSection load='8agg' size='340' side='right'caption='[[8agg]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8agg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AGG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8agg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8agg OCA], [https://pdbe.org/8agg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8agg RCSB], [https://www.ebi.ac.uk/pdbsum/8agg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8agg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LEM3_LEGPH LEM3_LEGPH] Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a phosphocholine hydrolase by mediating the hydrolysis of phosphocholine to Ser residues of host RAB1 (RAB1A, RAB1B or RAB1C). Dephosphocholination of target proteins restores accessibility to GTPase effector LepB. Can act on both GDP-bound and GTP-bound Rab proteins.<ref>PMID:22158903</ref> <ref>PMID:22307087</ref> <ref>PMID:22411835</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Legionella pneumophila]]
[[Category: Itzen A]]
[[Category: Kaspers MS]]
[[Category: Pogenberg V]]