View source for 8aic


==X-ray structure of the receptor binding domain of Env glycoprotein of Simian Foamy virus==
<StructureSection load='8aic' size='340' side='right'caption='[[8aic]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8aic]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_foamy_virus Simian foamy virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AIC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8aic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8aic OCA], [https://pdbe.org/8aic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8aic RCSB], [https://www.ebi.ac.uk/pdbsum/8aic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8aic ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/K7YEW5_9RETR K7YEW5_9RETR] The leader peptide is a component of released, infectious virions and is required for particle budding.[ARBA:ARBA00002261]  The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.[ARBA:ARBA00024648]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Simian foamy virus]]
[[Category: Backovic M]]
[[Category: Fernandez I]]