View source for 8ayu


==Crystal structure of SUDV VP40 L117A mutant==
<StructureSection load='8ayu' size='340' side='right'caption='[[8ayu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ayu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sudan_ebolavirus Sudan ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AYU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AYU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ayu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ayu OCA], [https://pdbe.org/8ayu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ayu RCSB], [https://www.ebi.ac.uk/pdbsum/8ayu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ayu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VP40_EBOSU VP40_EBOSU] Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway. May facilitate virus budding by interacting with the nucleocapsid and the plasma membrane. Specific interactions with membrane-associated GP and VP24 during the budding process may also occur. The hexamer form seems to be involved in budding. The octamer form binds RNA, and may play a role in genome replication (By similarity).
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</StructureSection>
[[Category: Large Structures]]
[[Category: Sudan ebolavirus]]
[[Category: Becker S]]
[[Category: Essen L-O]]
[[Category: Kowalski K]]
[[Category: Steinchen W]]
[[Category: Werel L]]
[[Category: Werner A-D]]