View source for 8bfj


==CNOT11-GGNBP2 complex==
<StructureSection load='8bfj' size='340' side='right'caption='[[8bfj]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8bfj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BFJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BFJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bfj OCA], [https://pdbe.org/8bfj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bfj RCSB], [https://www.ebi.ac.uk/pdbsum/8bfj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bfj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CNO11_HUMAN CNO11_HUMAN] Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Basquin J]]
[[Category: Conti E]]
[[Category: Ozgur S]]