View source for 8biq


==Crystal structure of acyl-COA synthetase from Metallosphaera sedula in complex with acetyl-AMP==
<StructureSection load='8biq' size='340' side='right'caption='[[8biq]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8biq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Metallosphaera_sedula_DSM_5348 Metallosphaera sedula DSM 5348]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BIQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6R9:[[(2~{R},3~{S},4~{R},5~{R})-5-(6-AMINOPURIN-9-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+ETHANOATE'>6R9</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8biq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8biq OCA], [https://pdbe.org/8biq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8biq RCSB], [https://www.ebi.ac.uk/pdbsum/8biq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8biq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HBCL1_METS5 HBCL1_METS5] Involved in the 3-hydroxypropionate/4-hydroxybutyrate cycle which incorporates carbon dioxide into cellular carbon. Catalyzes the ligation of coenzyme A (CoA) to 4-hydroxybutyrate (4HB). It can also use butyrate, valerate, propionate, acetate and 3-hydroxybutyrate (3HB) as substrates.<ref>PMID:23258541</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Metallosphaera sedula DSM 5348]]
[[Category: Capra N]]
[[Category: Janssen DB]]
[[Category: Thunnissen AMWH]]