View source for 8blp


==Human Urea Transporter UT-B/UT1 in Complex with Inhibitor UTBinh-14==
<StructureSection load='8blp' size='340' side='right'caption='[[8blp]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8blp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BLP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5D3:10-(4-ethylphenyl)sulfonyl-~{N}-(thiophen-2-ylmethyl)-5-thia-1,8,11,12-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine'>5D3</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8blp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8blp OCA], [https://pdbe.org/8blp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8blp RCSB], [https://www.ebi.ac.uk/pdbsum/8blp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8blp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UT1_HUMAN UT1_HUMAN] Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bohstedt T]]
[[Category: Bountra C]]
[[Category: Burgess-Brown NA]]
[[Category: Chi G]]
[[Category: Dietz L]]
[[Category: Duerr KL]]
[[Category: Edwards A]]
[[Category: Fernandez-Cid A]]
[[Category: Maclean EM]]
[[Category: McKinley G]]
[[Category: Mukhopadhyay SMM]]
[[Category: Pike ACW]]
[[Category: Scacioc A]]
[[Category: Wang D]]