View source for 8bs7


==Multimerisation domain of Borna disease virus 1==
<StructureSection load='8bs7' size='340' side='right'caption='[[8bs7]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8bs7]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Borna_disease_virus_1 Borna disease virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BS7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bs7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bs7 OCA], [https://pdbe.org/8bs7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bs7 RCSB], [https://www.ebi.ac.uk/pdbsum/8bs7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bs7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PHOSP_BDVV PHOSP_BDVV] Essential component of the RNA polymerase transcription and replication complex. Acts as a scaffold which brings L in close proximity to the N-RNA complex. Plays a role in the segregation of the viral genome in host daughter cells during mitosis by interacting with host HMGB1, a host chromatin-remodeling DNA architectural protein, thereby stabilizing RNP on chromosomes. Interacts with host TBK1 and thus interferes with activation of cellular antiviral state. Inhibits cellular histone acetyltransferase activities.[UniProtKB:P0C798]<ref>PMID:15509569</ref> <ref>PMID:22607802</ref> <ref>PMID:25810554</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Borna disease virus 1]]
[[Category: Large Structures]]
[[Category: Grimes JM]]
[[Category: Keown JR]]
[[Category: Whitehead JD]]