View source for 8btg


==Cryo-EM structure of the bacterial replication origin opening basal unwinding system==
<StructureSection load='8btg' size='340' side='right'caption='[[8btg]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8btg]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] and [https://en.wikipedia.org/wiki/DNA_molecule DNA molecule]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BTG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BTG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8btg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8btg OCA], [https://pdbe.org/8btg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8btg RCSB], [https://www.ebi.ac.uk/pdbsum/8btg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8btg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DNAA_BACSU DNAA_BACSU] Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. DnaA can inhibit its own gene expression as well as that of other genes.
__TOC__
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: DNA molecule]]
[[Category: Large Structures]]
[[Category: Bodet-Lefevre S]]
[[Category: Ilangovan A]]
[[Category: Murray H]]
[[Category: Pelliciari S]]