View source for 8buo


==Structure of DDB1 bound to DS24-engaged CDK12-cyclin K==
<StructureSection load='8buo' size='340' side='right'caption='[[8buo]], [[Resolution|resolution]] 3.58&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8buo]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BUO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.58&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RLC:(2~{R})-2-[[6-[(3-fluoranyl-4-pyridin-2-yl-phenyl)methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol'>RLC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8buo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8buo OCA], [https://pdbe.org/8buo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8buo RCSB], [https://www.ebi.ac.uk/pdbsum/8buo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8buo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CCNK_HUMAN CCNK_HUMAN] May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward both RNA polymerase II C-terminal domain and CDK2 (CAK).<ref>PMID:10574912</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kempf G]]
[[Category: Kozicka Z]]
[[Category: Petzold G]]
[[Category: Thoma NH]]