View source for 8buy


==Rac-binding domain of human MiniBAR==
<StructureSection load='8buy' size='340' side='right'caption='[[8buy]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8buy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BUY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8buy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8buy OCA], [https://pdbe.org/8buy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8buy RCSB], [https://www.ebi.ac.uk/pdbsum/8buy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8buy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GRRE1_HUMAN GRRE1_HUMAN] Acts as an effector of RAC1 (PubMed:31871319). Associates with CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:29395067). May also play a role in miRNA silencing machinery (PubMed:29395067).<ref>PMID:29395067</ref> <ref>PMID:31871319</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hammich H]]
[[Category: Houdusse A]]
[[Category: Pylypenko O]]