View source for 8bwa


==Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with platinum==
<StructureSection load='8bwa' size='340' side='right'caption='[[8bwa]], [[Resolution|resolution]] 3.61&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8bwa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BWA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.61&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bwa OCA], [https://pdbe.org/8bwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bwa RCSB], [https://www.ebi.ac.uk/pdbsum/8bwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bwa ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TWSG1_HUMAN TWSG1_HUMAN] May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ashe H]]
[[Category: Baldock C]]
[[Category: Belnoue-Davis H]]
[[Category: Duman R]]
[[Category: Eggington H]]
[[Category: El Omari K]]
[[Category: Griffiths SC]]
[[Category: Leedham SJ]]
[[Category: Malinauskas T]]
[[Category: Moore G]]
[[Category: Rudolf AF]]
[[Category: Siebold C]]
[[Category: Wagner A]]
[[Category: Woolley RE]]