View source for 8bwd


==Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1), crystal form 1==
<StructureSection load='8bwd' size='340' side='right'caption='[[8bwd]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8bwd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BWD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BWD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bwd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bwd OCA], [https://pdbe.org/8bwd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bwd RCSB], [https://www.ebi.ac.uk/pdbsum/8bwd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bwd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TWSG1_HUMAN TWSG1_HUMAN] May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ashe H]]
[[Category: Baldock C]]
[[Category: Belnoue-Davis H]]
[[Category: Duman R]]
[[Category: Eggington H]]
[[Category: El Omari K]]
[[Category: Griffiths SC]]
[[Category: Leedham SJ]]
[[Category: Malinauskas T]]
[[Category: Moore G]]
[[Category: Rudolf AF]]
[[Category: Siebold C]]
[[Category: Wagner A]]
[[Category: Woolley RE]]