View source for 8c8u


==Priestia megaterium mupirocin-resistant isoleucyl-tRNA synthetase 2 complexed with mupirocin==
<StructureSection load='8c8u' size='340' side='right'caption='[[8c8u]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8c8u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_megaterium Priestia megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C8U FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.901&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=MRC:MUPIROCIN'>MRC</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c8u OCA], [https://pdbe.org/8c8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c8u RCSB], [https://www.ebi.ac.uk/pdbsum/8c8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c8u ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0B6AVD3_PRIM2 A0A0B6AVD3_PRIM2] Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).[ARBA:ARBA00025217][HAMAP-Rule:MF_02003]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Priestia megaterium]]
[[Category: Ban N]]
[[Category: Brkic A]]
[[Category: Car Z]]
[[Category: Gruic-Sovulj I]]
[[Category: Jablonska J]]
[[Category: Leibundgut M]]
[[Category: Petrovic Perokovic V]]
[[Category: Zanki V]]