View source for 8cet


==Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO507==
<StructureSection load='8cet' size='340' side='right'caption='[[8cet]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8cet]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Monkeypox_virus Monkeypox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CET OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CET FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UGR:(2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-quinolin-3-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic+acid'>UGR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cet OCA], [https://pdbe.org/8cet PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cet RCSB], [https://www.ebi.ac.uk/pdbsum/8cet PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cet ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MCE_MONPV MCE_MONPV] Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap. At the 3' end, functions as a processivity factor which stimulates the activity of the viral poly(A) polymerase OPG063 that creates mRNA's poly(A) tail. In the presence of OPG102, OPG063 does not dissociate from the RNA allowing tail elongation to around 250 adenylates.[UniProtKB:P07617]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Monkeypox virus]]
[[Category: Boura E]]
[[Category: Klima M]]
[[Category: Silhan J]]