View source for 8cev


==Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO1119==
<StructureSection load='8cev' size='340' side='right'caption='[[8cev]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8cev]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Monkeypox_virus Monkeypox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CEV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CEV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UG9:(2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-azanyl-5-iodanyl-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic+acid'>UG9</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cev FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cev OCA], [https://pdbe.org/8cev PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cev RCSB], [https://www.ebi.ac.uk/pdbsum/8cev PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cev ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MCE_MONPV MCE_MONPV] Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap. At the 3' end, functions as a processivity factor which stimulates the activity of the viral poly(A) polymerase OPG063 that creates mRNA's poly(A) tail. In the presence of OPG102, OPG063 does not dissociate from the RNA allowing tail elongation to around 250 adenylates.[UniProtKB:P07617]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Monkeypox virus]]
[[Category: Boura E]]
[[Category: Klima M]]
[[Category: Silhan J]]