View source for 8cie


==Crystal structure of the human CDKL5 kinase domain with compound YL-354==
<StructureSection load='8cie' size='340' side='right'caption='[[8cie]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8cie]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CIE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=US0:4-[[3,5-bis(fluoranyl)phenyl]carbonylamino]-~{N}-piperidin-4-yl-1~{H}-pyrazole-3-carboxamide'>US0</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cie OCA], [https://pdbe.org/8cie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cie RCSB], [https://www.ebi.ac.uk/pdbsum/8cie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cie ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CDKL5_HUMAN CDKL5_HUMAN] Note=Chromosomal aberrations involving CDKL5 are found in patients manifesting early-onset seizures and spams and psychomotor impairment. Translocation t(X;6)(p22.3;q14); translocation t(X;7)(p22.3;p15).  Epileptic encephalopathy, early infantile, 2 (EIEE2) [MIM:[https://omim.org/entry/300672 300672]: A severe form of epilepsy characterized by seizures or spasms beginning in infancy. Patients with epileptic encephalopathy early infantile type 2 manifest features resembling Rett syndrome such as microcephaly, lack of speech development, stereotypic hand movements. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:15917271</ref> <ref>PMID:16935860</ref> <ref>PMID:12736870</ref> <ref>PMID:15492925</ref> <ref>PMID:15499549</ref> <ref>PMID:15689447</ref> <ref>PMID:16015284</ref> <ref>PMID:16611748</ref> <ref>PMID:18790821</ref> <ref>PMID:17993579</ref> <ref>PMID:18809835</ref> <ref>PMID:19253388</ref> <ref>PMID:19241098</ref> 
== Function ==
[https://www.uniprot.org/uniprot/CDKL5_HUMAN CDKL5_HUMAN] Mediates phosphorylation of MECP2.<ref>PMID:15917271</ref> <ref>PMID:16935860</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bakshi S]]
[[Category: Brooke L]]
[[Category: Bullock AN]]
[[Category: Chen X]]
[[Category: Lakshminarayana B]]
[[Category: Newman JA]]
[[Category: Richardson W]]