View source for 8ciz


==DNA-polymerase sliding clamp (DnaN) from Escherichia coli in complex with Mycoplanecin A.==
<StructureSection load='8ciz' size='340' side='right'caption='[[8ciz]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ciz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinoplanes_awajinensis_subsp._mycoplanecinus Actinoplanes awajinensis subsp. mycoplanecinus] and [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CIZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2KT:2-KETOBUTYRIC+ACID'>2KT</scene>, <scene name='pdbligand=HLX:5-METHYL-L-NORLEUCINE'>HLX</scene>, <scene name='pdbligand=MLU:N-METHYL-D-LEUCINE'>MLU</scene>, <scene name='pdbligand=MP8:(4R)-4-METHYL-L-PROLINE'>MP8</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=NZC:N-METHYLIDENE-L-THREONINE'>NZC</scene>, <scene name='pdbligand=V3C:Trans-4-athyl-L-proline'>V3C</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ciz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ciz OCA], [https://pdbe.org/8ciz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ciz RCSB], [https://www.ebi.ac.uk/pdbsum/8ciz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ciz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DPO3B_ECOLI DPO3B_ECOLI] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA.
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</StructureSection>
[[Category: Actinoplanes awajinensis subsp. mycoplanecinus]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Bader C]]
[[Category: Blankenfeldt W]]
[[Category: Fu C]]
[[Category: Kalinina O]]
[[Category: Liu Y]]
[[Category: Lukat P]]
[[Category: Mueller R]]
[[Category: Neuber M]]
[[Category: Rasheed S]]
[[Category: Walt C]]