View source for 8cll


==Structural insights into human TFIIIC promoter recognition==
<StructureSection load='8cll' size='340' side='right'caption='[[8cll]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8cll]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CLL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cll OCA], [https://pdbe.org/8cll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cll RCSB], [https://www.ebi.ac.uk/pdbsum/8cll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cll ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TF3C4_HUMAN TF3C4_HUMAN] Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Christoph M]]
[[Category: Luis H]]
[[Category: Mathias G]]
[[Category: Sebastian E]]
[[Category: Thomas H]]
[[Category: Wolfram SD]]