View source for 8cs4


==[AGC/GTC] Self-Assembled 3D DNA Hexagonal Tensegrity Triangle==
<StructureSection load='8cs4' size='340' side='right'caption='[[8cs4]], [[Resolution|resolution]] 6.03&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8cs4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CS4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CS4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 6.03&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cs4 OCA], [https://pdbe.org/8cs4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cs4 RCSB], [https://www.ebi.ac.uk/pdbsum/8cs4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cs4 ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
&lt;p class="Text" style="margin: 0in 0in 8pt; text-align: justify; line-height: 24px; font-size: 12pt; font-family: &quot;Times New Roman&quot;, serif; color: rgb(0, 0, 0);"&gt;Non-canonical interactions in DNA remain under-explored in DNA nanotechnology. Recently, many structures with non-canonical motifs have been discovered, notably a hexagonal arrangement of typically rhombohedral DNA tensegrity triangles that forms through non-canonical sticky end interactions. Here, we find a series of mechanisms to program a hexagonal arrangement using: the sticky end sequence; triangle edge torsional stress; and crystallization condition. We showcase cross-talking between Watson-Crick and non-canonical sticky ends in which the ratio between the two dictates segregation by crystal forms or combination into composite crystals. Finally, we develop a method for reconfiguring the long-range geometry of formed crystals from rhombohedral to hexagonal and &lt;italic&gt;vice versa&lt;/italic&gt;. These data demonstrate fine control over non-canonical motifs and their topological self-assembly. This will vastly increase the programmability, functionality, and versatility of rationally designed DNA constructs.&lt;o:p&gt;&lt;/o:p&gt;&lt;/p&gt;.

Programmable 3D Hexagonal Geometry of DNA Tensegrity Triangles.,Lu B, Woloszyn K, Ohayon YP, Yang B, Zhang C, Mao C, Seeman NC, Vecchioni S, Sha R Angew Chem Int Ed Engl. 2022 Dec 15. doi: 10.1002/anie.202213451. PMID:36520622<ref>PMID:36520622</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 8cs4" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Lu B]]
[[Category: Mao C]]
[[Category: Ohayon YP]]
[[Category: Seeman NC]]
[[Category: Sha R]]
[[Category: Vecchioni S]]