View source for 8csl


==Sub-tomogram averaging of erythrocyte ankyrin-1 complex==
<StructureSection load='8csl' size='340' side='right'caption='[[8csl]], [[Resolution|resolution]] 25.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8csl]] is a 19 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CSL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 25&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8csl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8csl OCA], [https://pdbe.org/8csl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8csl RCSB], [https://www.ebi.ac.uk/pdbsum/8csl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8csl ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ANK1_HUMAN ANK1_HUMAN] Defects in ANK1 are a cause of spherocytosis type 1 (SPH1) [MIM:[https://omim.org/entry/182900 182900]; also called hereditary spherocytosis type 1 (HS1). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Inheritance can be autosomal dominant or recessive.<ref>PMID:8640229</ref> <ref>PMID:11102985</ref> 
== Function ==
[https://www.uniprot.org/uniprot/ANK1_HUMAN ANK1_HUMAN] Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions.<ref>PMID:12456646</ref>   Isoform Mu17 together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils.<ref>PMID:12456646</ref> 

==See Also==
*[[Ankyrin 3D structures|Ankyrin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cali T]]
[[Category: Clarke OB]]
[[Category: Johnston JD]]
[[Category: Kim K]]
[[Category: Noble AJ]]
[[Category: Vallese F]]
[[Category: Yen LY]]