View source for 8cuc


==Crystal structure analysis of SALL4 zinc finger domain in complex with DNA==
<StructureSection load='8cuc' size='340' side='right'caption='[[8cuc]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8cuc]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CUC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CUC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cuc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cuc OCA], [https://pdbe.org/8cuc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cuc RCSB], [https://www.ebi.ac.uk/pdbsum/8cuc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cuc ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SALL4_HUMAN SALL4_HUMAN] Acro-renal-ocular syndrome;IVIC syndrome;Okihiro syndrome due to 20q13 microdeletion;Okihiro syndrome due to a point mutation. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/SALL4_HUMAN SALL4_HUMAN] Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells.<ref>PMID:23012367</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dhe-Paganon S]]
[[Category: Seo HS]]