View source for 8cxk


==Structure of the C. elegans HIM-3 R93Y mutant==
<StructureSection load='8cxk' size='340' side='right'caption='[[8cxk]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8cxk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CXK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cxk OCA], [https://pdbe.org/8cxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cxk RCSB], [https://www.ebi.ac.uk/pdbsum/8cxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cxk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G5EBG0_CAEEL G5EBG0_CAEEL] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
During meiotic prophase, the essential events of homolog pairing, synapsis, and recombination are coordinated with meiotic progression to promote fidelity and prevent aneuploidy. The conserved AAA+ ATPase PCH-2 coordinates these events to guarantee crossover assurance and accurate chromosome segregation. How PCH-2 accomplishes this coordination is poorly understood. Here, we provide evidence that PCH-2 decelerates pairing, synapsis and recombination in C. elegans by remodeling meiotic HORMADs. We propose that PCH-2 converts the closed versions of these proteins, which drive these meiotic prophase events, to unbuckled conformations, destabilizing interhomolog interactions and delaying meiotic progression. Further, we find that PCH-2 distributes this regulation among three essential meiotic HORMADs in C. elegans: PCH-2 acts through HTP-3 to regulate pairing and synapsis, HIM-3 to promote crossover assurance, and HTP-1 to control meiotic progression. In addition to identifying a molecular mechanism for how PCH-2 regulates interhomolog interactions, our results provide a possible explanation for the expansion of the meiotic HORMAD family as a conserved evolutionary feature of meiosis. Taken together, our work demonstrates that PCH-2's remodeling of meiotic HORMADs has functional consequences for the rate and fidelity of homolog pairing, synapsis, recombination and meiotic progression, ensuring accurate meiotic chromosome segregation.

The conserved AAA ATPase PCH-2 distributes its regulation of meiotic prophase events through multiple meiotic HORMADs in C. elegans.,Russo AE, Giacopazzi S, Deshong A, Menon M, Ortiz V, Ego KM, Corbett KD, Bhalla N PLoS Genet. 2023 Apr 14;19(4):e1010708. doi: 10.1371/journal.pgen.1010708. , eCollection 2023 Apr. PMID:37058535<ref>PMID:37058535</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 8cxk" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Large Structures]]
[[Category: Bhalla N]]
[[Category: Corbett KD]]
[[Category: Deshong A]]
[[Category: Ego KM]]
[[Category: Giacopazzi S]]
[[Category: Menon M]]
[[Category: Ortiz V]]
[[Category: Russo A]]