View source for 8dae


==Arabidopsis thaliana bifunctional dihydrofolate reductase-thymidylate synthase==
<StructureSection load='8dae' size='340' side='right'caption='[[8dae]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8dae]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DAE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DAE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dae OCA], [https://pdbe.org/8dae PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dae RCSB], [https://www.ebi.ac.uk/pdbsum/8dae PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dae ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DRTS1_ARATH DRTS1_ARATH] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate: de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Bond CS]]
[[Category: Haywood J]]