View source for 8db0


==Crystal structure of DMATS1 prenyltransferase in complex with L-Trp and DMSPP==
<StructureSection load='8db0' size='340' side='right'caption='[[8db0]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8db0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusarium_fujikuroi Fusarium fujikuroi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DB0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DB0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DST:DIMETHYLALLYL+S-THIOLODIPHOSPHATE'>DST</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PE8:3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL'>PE8</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8db0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8db0 OCA], [https://pdbe.org/8db0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8db0 RCSB], [https://www.ebi.ac.uk/pdbsum/8db0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8db0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DMAT1_GIBF5 DMAT1_GIBF5] Dimethylallyltryptophan synthase; part of the DMATS1 gene cluster that mediates the biosynthesis of a reversely N-prenylated monomeric L-tryptophan (r-N-DMAT) (PubMed:28295904). The main product of the cluster is the r-N-DMAT produced by the dimethylallyltryptophan synthase DMATS1 and it remains unclear whether this metabolite undergoes further modifications when silent gene clusters are activated (PubMed:28295904). The acetylated form of r-N-DMAT, ac-r-N-DMAT, is also produced (PubMed:28295904). The roles of the cytochrome P450 monooxygenase FFUJ_09176 and the methyltransferase FFUJ_09178 have still to be elucidated (Probable).<ref>PMID:28295904</ref> <ref>PMID:28295904</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Fusarium fujikuroi]]
[[Category: Large Structures]]
[[Category: Christianson DW]]
[[Category: Eaton SA]]
[[Category: Ronnebaum TA]]
[[Category: Roose BW]]