View source for 8dfz


==NMR shows why a small chemical change almost abolishes the antimicrobial activity of GccF==
<StructureSection load='8dfz' size='340' side='right'caption='[[8dfz]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8dfz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactiplantibacillus_plantarum Lactiplantibacillus plantarum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DFZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DFZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EW6:alpha-methyl-L-serine'>EW6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dfz OCA], [https://pdbe.org/8dfz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dfz RCSB], [https://www.ebi.ac.uk/pdbsum/8dfz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dfz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GCCF_LACPN GCCF_LACPN] Has antibacterial activity against L.plantarum ATCC 8014. In purified form, the activity is bacteriostatic (IC(50)=2 nM) rather than bactericidal.<ref>PMID:21251913</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Lactiplantibacillus plantarum]]
[[Category: Large Structures]]
[[Category: Edwards PJB]]
[[Category: Harjes E]]
[[Category: Norris G]]