View source for 8dl7


==Cryo-EM structure of human ferroportin/slc40 bound to minihepcidin PR73 in nanodisc==
<StructureSection load='8dl7' size='340' side='right'caption='[[8dl7]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8dl7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DL7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2GX:BETA-PHENYL-L-PHENYLALANINE'>2GX</scene>, <scene name='pdbligand=3FB:(3S)-3-AMINO-4-PHENYLBUTANOIC+ACID'>3FB</scene>, <scene name='pdbligand=ACA:6-AMINOHEXANOIC+ACID'>ACA</scene>, <scene name='pdbligand=EOE:beta3-proline'>EOE</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene>, <scene name='pdbligand=SOW:[(2-amino-2-oxoethyl)amino]acetic+acid'>SOW</scene>, <scene name='pdbligand=SQ6:2,2-azanediyldiacetic+acid'>SQ6</scene>, <scene name='pdbligand=SQI:hexadecan-1-amine'>SQI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dl7 OCA], [https://pdbe.org/8dl7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dl7 RCSB], [https://www.ebi.ac.uk/pdbsum/8dl7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dl7 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/S40A1_HUMAN S40A1_HUMAN] Hemochromatosis type 4. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/S40A1_HUMAN S40A1_HUMAN] Major iron transporter that plays a key role in balancing cellular and systemic iron levels (PubMed:29237594, PubMed:22682227, PubMed:15692071). Transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages, and release of iron stores in hepatocytes (By similarity). When iron is in excess, hepcidin/HAMP levels increase resulting in a degradation of ferroportin/SLC40A1 limiting the iron efflux to plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342).[UniProtKB:Q9JHI9]<ref>PMID:15692071</ref> <ref>PMID:22682227</ref> <ref>PMID:29237594</ref> <ref>PMID:32814342</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Synthetic construct]]
[[Category: Pan Y]]
[[Category: Shen J]]
[[Category: Wilbon AS]]
[[Category: Zhou M]]