View source for 8dwv


==Full-length wild type SPOP==
<StructureSection load='8dwv' size='340' side='right'caption='[[8dwv]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8dwv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DWV FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dwv OCA], [https://pdbe.org/8dwv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dwv RCSB], [https://www.ebi.ac.uk/pdbsum/8dwv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dwv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SPOP_HUMAN SPOP_HUMAN] Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (By similarity). In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3.<ref>PMID:14528312</ref> <ref>PMID:15897469</ref> <ref>PMID:16524876</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cuneo MJ]]
[[Category: Lo YH]]
[[Category: Mittag T]]
[[Category: O'Flynn B]]