View source for 8ecy


==cryoEM structure of bovine bestrophin-2 and glutamine synthetase complex==
<StructureSection load='8ecy' size='340' side='right'caption='[[8ecy]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ecy]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ECY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ECY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ecy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ecy OCA], [https://pdbe.org/8ecy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ecy RCSB], [https://www.ebi.ac.uk/pdbsum/8ecy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ecy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BEST2_BOVIN BEST2_BOVIN] Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by calcium (Ca2+) (PubMed:32251414, PubMed:36289327). Transports a large specter of anions, namely mediates the movement of chloride, L-glutamate and iodide (PubMed:32251414, PubMed:36289327). Calcium-binding triggers the dilation of the aperture, but calcium-dependent gating is only effective when the size of the passing anion is bigger than the closed aperture (PubMed:32251414). Mediates the calcium-activated hydrogencarbonate movement and participates in colonic hydrogencarbonate secretion concomitant with mucin secretion (By similarity). In non-pigmented epithelium (NPE), mediates the efflux of intracellular L-glutamate; binding of intracellular L-glutamate activates and open both the neck and the aperture of the channel, leading to L-glutamate exit promoting chloride influx movement from the extracellular side in trans (By similarity). Also exhibits a directional permeability for intracellular glutamine, in a similar manner as for L-glutamate (By similarity).[UniProtKB:Q8BGM5][UniProtKB:Q8NFU1]<ref>PMID:32251414</ref> <ref>PMID:36289327</ref> 

==See Also==
*[[Glutamine synthetase 3D structures|Glutamine synthetase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Large Structures]]
[[Category: Kittredge AK]]
[[Category: Owji AP]]
[[Category: Yang T]]