View source for 8efp


==CryoEM structure of GSDMB in complex with shigella IpaH7.8==
<StructureSection load='8efp' size='340' side='right'caption='[[8efp]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8efp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EFP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8efp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8efp OCA], [https://pdbe.org/8efp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8efp RCSB], [https://www.ebi.ac.uk/pdbsum/8efp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8efp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IPA7_SHIFL IPA7_SHIFL] E3 ubiquitin ligase effector protein that interferes with host's innate immunity (PubMed:30872533, PubMed:34022140, PubMed:34492225, PubMed:36599845, PubMed:36991122, PubMed:36991125). Functions to alter host cell physiology and promote bacterial survival in host tissues (PubMed:30872533, PubMed:34022140, PubMed:34492225). Catalyzes ubiquitination of human gasdermins GSDMB and GSDMD, promoting their degradation by the proteasome, thereby preventing cell death (PubMed:34022140, PubMed:34492225, PubMed:36599845, PubMed:36991122, PubMed:36991125). In contrast, activates host cell pyroptosis in mouse cells: catalyzes ubiquitination of mouse Nlrp1b allele 1 protein, releasing the cleaved C-terminal part of Nlrp1b, which polymerizes and forms the Nlrp1b inflammasome followed by host cell pyroptosis (PubMed:30872533). Does not catalyze ubiquitination of mouse GSDMD (PubMed:36599845, PubMed:36991122, PubMed:36991125).<ref>PMID:30872533</ref> <ref>PMID:34022140</ref> <ref>PMID:34492225</ref> <ref>PMID:36599845</ref> <ref>PMID:36991122</ref> <ref>PMID:36991125</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Shigella flexneri]]
[[Category: Ruan J]]
[[Category: Wang C]]