View source for 8ekt


==CYP51 from Acanthamoeba castellanii in complex with the tetrazole-based IND inhibitor VT-1161(VT1)==
<StructureSection load='8ekt' size='340' side='right'caption='[[8ekt]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ekt]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Acanthamoeba_castellanii Acanthamoeba castellanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EKT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VT1:(R)-2-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-3-(1H-TETRAZOL-1-YL)-1-(5-(4-(2,2,2-TRIFLUOROETHOXY)PHENYL)PYRIDIN-2-YL)PROPAN-2-OL'>VT1</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ekt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ekt OCA], [https://pdbe.org/8ekt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ekt RCSB], [https://www.ebi.ac.uk/pdbsum/8ekt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ekt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/L8GJB3_ACACF L8GJB3_ACACF] 
__TOC__
</StructureSection>
[[Category: Acanthamoeba castellanii]]
[[Category: Large Structures]]
[[Category: Hargrove TY]]
[[Category: Lepesheva GI]]
[[Category: Wawrzak Z]]