View source for 8eqj


==Structure of SARS-CoV-2 Orf3a in late endosome/lysosome-like membrane environment, MSP1D1 nanodisc==
<StructureSection load='8eqj' size='340' side='right'caption='[[8eqj]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8eqj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EQJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8eqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8eqj OCA], [https://pdbe.org/8eqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8eqj RCSB], [https://www.ebi.ac.uk/pdbsum/8eqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8eqj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AP3A_SARS2 AP3A_SARS2] Forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. Up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. Induces apoptosis in cell culture. Downregulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination.[UniProtKB:P59632]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Severe acute respiratory syndrome coronavirus 2]]
[[Category: Brauchi SE]]
[[Category: Cabezas-Bratesco D]]
[[Category: Clapham DE]]
[[Category: Cristofori-Armstrong B]]
[[Category: Dilan TL]]
[[Category: Houlihan PR]]
[[Category: Lee GY]]
[[Category: Matamala E]]
[[Category: Matthies D]]
[[Category: Miller AN]]
[[Category: Ren D]]
[[Category: Sanchez-Martinez S]]
[[Category: Yan R]]
[[Category: Yu Z]]