View source for 8eqs


==Structure of SARS-CoV-1 Orf3a in late endosome/lysosome-like environment, MSP1D1 nanodisc==
<StructureSection load='8eqs' size='340' side='right'caption='[[8eqs]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8eqs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus Severe acute respiratory syndrome coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EQS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8eqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8eqs OCA], [https://pdbe.org/8eqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8eqs RCSB], [https://www.ebi.ac.uk/pdbsum/8eqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8eqs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AP3A_SARS AP3A_SARS] Forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. Up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. Induces apoptosis in cell culture. Down-regulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination.<ref>PMID:15958670</ref> <ref>PMID:16014971</ref> <ref>PMID:16894145</ref> <ref>PMID:20020050</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Severe acute respiratory syndrome coronavirus]]
[[Category: Brauchi SE]]
[[Category: Cabezas-Bratesco D]]
[[Category: Clapham DE]]
[[Category: Cristofori-Armstrong B]]
[[Category: Dilan TL]]
[[Category: Houlihan PR]]
[[Category: Lee GY]]
[[Category: Matamala E]]
[[Category: Matthies D]]
[[Category: Miller AN]]
[[Category: Ren D]]
[[Category: Sanchez-Martinez S]]
[[Category: Yan R]]
[[Category: Yu Z]]