View source for 8esm


==Human triacylglycerol synthesizing enzyme DGAT1 in complex with T863 inhibitor==
<StructureSection load='8esm' size='340' side='right'caption='[[8esm]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8esm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ESM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ESM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WS0:{(1r,4r)-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl}acetic+acid'>WS0</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8esm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8esm OCA], [https://pdbe.org/8esm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8esm RCSB], [https://www.ebi.ac.uk/pdbsum/8esm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8esm ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/DGAT1_HUMAN DGAT1_HUMAN] Congenital chronic diarrhea with protein-losing enteropathy. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/DGAT1_HUMAN DGAT1_HUMAN] Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.<ref>PMID:16214399</ref> <ref>PMID:9756920</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Farese R]]
[[Category: Kun W]]
[[Category: Liao M]]
[[Category: Sui X]]
[[Category: Walther T]]