View source for 8eu6


==Acheta domesticus segmented densovirus high buoyancy fraction 1 (HB1) empty capsid structure==
<StructureSection load='8eu6' size='340' side='right'caption='[[8eu6]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8eu6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Solenopsis_invicta-associated_densovirus Solenopsis invicta-associated densovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EU6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EU6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8eu6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8eu6 OCA], [https://pdbe.org/8eu6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8eu6 RCSB], [https://www.ebi.ac.uk/pdbsum/8eu6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8eu6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A891H5C3_9VIRU A0A891H5C3_9VIRU] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Parvoviruses (family Parvoviridae) are currently defined by a linear monopartite ssDNA genome, T = 1 icosahedral capsids, and distinct structural (VP) and non-structural (NS) protein expression cassettes within their genome. We report the discovery of a parvovirus with a bipartite genome, Acheta domesticus segmented densovirus (AdSDV), isolated from house crickets (Acheta domesticus), in which it is pathogenic. We found that the AdSDV harbors its NS and VP cassettes on two separate genome segments. Its vp segment acquired a phospholipase A2-encoding gene, vpORF3, via inter-subfamily recombination, coding for a non-structural protein. We showed that the AdSDV evolved a highly complex transcription profile in response to its multipartite replication strategy compared to its monopartite ancestors. Our structural and molecular examinations revealed that the AdSDV packages one genome segment per particle. The cryo-EM structures of two empty- and one full-capsid population (3.3, 3.1 and 2.3 A resolution) reveal a genome packaging mechanism, which involves an elongated C-terminal tail of the VP, "pinning" the ssDNA genome to the capsid interior at the twofold symmetry axis. This mechanism fundamentally differs from the capsid-DNA interactions previously seen in parvoviruses. This study provides new insights on the mechanism behind ssDNA genome segmentation and on the plasticity of parvovirus biology.

,  PMID:37316488<ref>PMID:37316488</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 8eu6" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Solenopsis invicta-associated densovirus]]
[[Category: McKenna R]]
[[Category: Penzes JJ]]
[[Category: Tijssen P]]