View source for 8ewu


==X-ray structure of the GDP-6-deoxy-4-keto-D-lyxo-heptose-4-reductase from Campylobacter jejuni HS:15==
<StructureSection load='8ewu' size='340' side='right'caption='[[8ewu]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ewu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni Campylobacter jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EWU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EWU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ewu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ewu OCA], [https://pdbe.org/8ewu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ewu RCSB], [https://www.ebi.ac.uk/pdbsum/8ewu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ewu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/F2X7A6_CAMJU F2X7A6_CAMJU] Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.[HAMAP-Rule:MF_00956]
__TOC__
</StructureSection>
[[Category: Campylobacter jejuni]]
[[Category: Large Structures]]
[[Category: Ghosh MK]]
[[Category: Holden HM]]
[[Category: Raushel FM]]
[[Category: Riegert AS]]
[[Category: Thoden JB]]
[[Category: Xiang DF]]