View source for 8exf


==Crystal structure of human FAM46A-BCCIPa complex at 3.2 angstrom resolution==
<StructureSection load='8exf' size='340' side='right'caption='[[8exf]], [[Resolution|resolution]] 3.22&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8exf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EXF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.22&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8exf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8exf OCA], [https://pdbe.org/8exf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8exf RCSB], [https://www.ebi.ac.uk/pdbsum/8exf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8exf ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TET5A_HUMAN TET5A_HUMAN] Osteogenesis imperfecta type 3. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/TET5A_HUMAN TET5A_HUMAN] Cytoplasmic non-canonical poly(A) RNA polymerase that catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and participates in the cytoplasmic polyadenylation (PubMed:33882302). Polyadenylates mRNA encoding extracellular matrix constituents and other genes crucial for bone mineralization and during osteoblast mineralization, mainly focuses on ER-targeted mRNAs (By similarity).[UniProtKB:D3Z5S8]<ref>PMID:33882302</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Liu S]]
[[Category: Zhang X]]