View source for 8exx


==Herpes simplex virus 1 polymerase holoenzyme bound to DNA and foscarnet (pre-translocation state)==
<StructureSection load='8exx' size='340' side='right'caption='[[8exx]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8exx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_KOS Human alphaherpesvirus 1 strain KOS] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EXX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8exx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8exx OCA], [https://pdbe.org/8exx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8exx RCSB], [https://www.ebi.ac.uk/pdbsum/8exx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8exx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/H9E937_HHV1 H9E937_HHV1] Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication.[ARBA:ARBA00025601]
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</StructureSection>
[[Category: Human alphaherpesvirus 1 strain KOS]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Abraham J]]
[[Category: Coen DM]]
[[Category: Hogle J]]
[[Category: Pan J]]
[[Category: Shankar S]]
[[Category: Yang P]]