View source for 8fay


==Human MUTYH adenine glycosylase bound to DNA containing a transition state analog (1N) paired with d(8-oxo-G)==
<StructureSection load='8fay' size='340' side='right'caption='[[8fay]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8fay]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FAY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8OG:8-OXO-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>8OG</scene>, <scene name='pdbligand=NR1:(3R,4R)-3-HYDROXY-4-[(PHOSPHONOOXY)METHYL]PYRROLIDINIUM'>NR1</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fay OCA], [https://pdbe.org/8fay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fay RCSB], [https://www.ebi.ac.uk/pdbsum/8fay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fay ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/MUTYH_HUMAN MUTYH_HUMAN] Defects in MUTYH are a cause of familial adenomatous polyposis type 2 (FAP2) [MIM:[https://omim.org/entry/608456 608456]. A condition characterized by the development of multiple colorectal adenomatous polyps, benign neoplasms derived from glandular epithelium. Some affected individuals may develop colorectal carcinoma.<ref>PMID:11818965</ref> <ref>PMID:12853198</ref> <ref>PMID:12606733</ref> <ref>PMID:15366000</ref> <ref>PMID:18091433</ref> <ref>PMID:19953527</ref>   Defects in MUTYH are a cause of gastric cancer (GASC) [MIM:[https://omim.org/entry/613659 613659]. A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.<ref>PMID:15273732</ref> 
== Function ==
[https://www.uniprot.org/uniprot/MUTYH_HUMAN MUTYH_HUMAN] Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.<ref>PMID:10684930</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: David SS]]
[[Category: Demir M]]
[[Category: Fisher AJ]]
[[Category: Horvath MP]]
[[Category: Lin WJ]]
[[Category: Trasvina-Arenas CH]]